研究揭示评估结核病发病的新方法Nat

SCI

9November

Discoveryandvalidationofapersonalizedriskpredictorforincidenttuberculosisinlowtransmissionsettings

GuptaRishiK,CalderwoodClaireJ,YavlinskyAlexeietal.Discoveryandvalidationofapersonalizedriskpredictorforincidenttuberculosisinlowtransmissionsettings.[J].NatMed,,undefined:undefined.

Theriskoftuberculosis(TB)isvariableamongindividualswithlatentMycobacteriumtuberculosisinfection(LTBI),butvalidatedestimatesofpersonalizedriskarelacking.Inpooleddatafrom18systematicallyidentifiedcohortstudiesfrom20countries,including80,individualstestedforLTBI,5-yearcumulativeincidentTBriskamongpeoplewithuntreatedLTBIwas15.6%(95%?confidenceinterval(CI),8.0-29.2%)amongchildcontacts,4.8%(95%CI,3.0-7.7%)amongadultcontacts,5.0%(95%CI,1.6-14.5%)amongmigrantsand4.8%(95%CI,1.5-14.3%)amongimmuno

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